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Additional insights into this topic comes from Marzieh Salehi and colleagues in a paper just published in Diabetes

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In a pooled analysis of the two monotherapy trials, the add-on to metformin trial, and the add-on to pioglitazone trial, the overall incidence of adverse reactions of hypoglycemia was 1.2% in patients treated with sitagliptin 100 mg and 0.9% in patients treated with placebo

In human plasma, UA metabolizes to around 55% in about 5 min after production

These actions directly lower fasting glucose and postprandial blood sugar spikes, both of which show up clearly on metabolic panels

L.Leverrier-PennaS.GicquelT.GitonF.CostetN.Desdoits-LethimonierC.et al (2022)