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Such inhibitor peptides, destabilizing the protein-protein interactions at immune checkpoints are designed using rational designing from known structures, empirical designing from sequence data and computational technology followed by phage display [23]

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Pharmacol Res 158:104844 Kamarajan P, Rajendiran TM, Kinchen J, Bermdez M, Danciu T, Kapila YL (2017) Head and neck squamous cell carcinoma metabolism draws on glutaminolysis, and stemness is specifically regulated by glutaminolysis via aldehyde dehydrogenase