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Potential theoretical concerns include: Unregulated angiogenesis Immune system modulation Tumor growth acceleration under certain conditions Reproductive safety implications Cardiovascular remodeling There is no clinical evidence demonstrating these risks in humans, but comprehensive trials evaluating these endpoints do not exist

EMA, 2017

Sivanandy P, Leey TC, Xiang TC, Ling TC, Wey Han SA, Semilan SLA, et al

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Side Effects To Watch Out For In clinical trials, most migraine patients have used dihydroergotamine mesylate nasal spray without serious side effects

If possible, work inside a laminar flow hood or sterile workspace to minimise airborne contamination