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Nausea is the most frequently reported issue, especially during dose escalations

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After initiation of RYBELSUS or OZEMPIC tablets, observe patients carefully for signs and symptoms of acute pancreatitis, which may include persistent or severe abdominal pain (sometimes radiating to the back), and which may or may not be accompanied by nausea or vomiting

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Your risk depends on whether you already experience post-cholecystectomy syndrome

And the central GLP-1 thirst suppression can mask your body need for water