Safety Considerations and When to Contact Your Provider Semaglutide is generally well-tolerated in people on levothyroxine, but notify your healthcare team of any changes: increased fatigue (may indicate under-replacement of thyroid hormone), heart palpitations, or mood shifts
"Health Canada New Drug Authorizations: 2015 Highlights"
Potential blood pressure and cholesterol benefits Individuals on GLP-1 agonists have seen blood pressure and cholesterol improvements
Medication access can take several weeks due to insurance steps, and there are no options for compounded or cash-pay GLP-1s
FDA-approved oral semaglutide The FDA has approved oral semaglutide (Rybelsus) for type 2 diabetes, and in early 2026, oral semaglutide received FDA approval for weight loss as well
Effect of hypoosmotic swelling test and water test on the distribution of sperm subpopulations in bull