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Folinic acid produced significant improvements in global ADOS score, social interaction, and communication, whereas placebo showed no meaningful change (Renard et al., 2020)
Proc Natl Acad Sci USA 102 : 1330113306
doi:10.1080/09546634.2022.2062282
Recent data suggest that SAM coordinately regulates homocysteine remethylation and catabolism by inhibiting methionine-conserving enzymes with low K m values and activating methionine-catabolizing enzymes with higher K m values (Finkelstein, 1990