Slowly, your body weight will go down
More data are needed to clarify the effects of GLP-1RAs on the incidence of OA, RA, PsA and axSpA, as well as on disease activity and progression in these conditions
At a glance: AOA-flagged ocular risks NAION (Non-Arteritic Anterior Ischemic Optic Neuropathy) Identified as a very rare but serious risk associated with semaglutide, the most prescribed GLP-1RA (Ozempic, Wegovy, Rybelsus) Up to 2 increased risk with semaglutide use After conducting risk assessment, the European Medicines Agency (EMA) calls for updated product info to list NAION as a very rare side effect Signs: Sudden, painless unilateral vision loss, visual field defect, dyschromatopsia, and optic disc swelling Discontinue GLP1RA and refer immediately if NAION is suspected Diabetic retinopathy (DR) progression In the SUSTAIN-6 trial, semaglutide users showed a higher rate of DR complications (3.0%) than placebo (1.8%) This may result from rapid HbA1c reduction, a known contributor to early DR worsening Especially concerning in patients with preexisting DR Perform a baseline dilated eye exam and follow up within 1218 months of treatment initiation Neovascular AMD A population-based study found GLP-1RA users had a 2 higher relative risk of developing wet AMD (0.2% vs 0.1%) Though absolute risk remains low, the potential impact is vision-threatening Closely monitor individuals with AMD risk factors or history Other rare events Isolated reports of: Uveitis Diplopia Optic neuropathies beyond NAION These are not yet confirmed by large-scale trials but suggest the need for comprehensive baseline evaluations
Unlike traditional medications that often affect multiple systems (and carry many side effects), peptides can be extremely targetedsupporting specific tissues, organs, or processes with minimal disruption elsewhere
& Nunez, G
These studies should incorporate sensitive biomarkers, including neuroimaging (MRI-based volumetry and functional connectivity), cerebrospinal fluid A/tau ratios, and emerging blood-based markers of oxidative stress and inflammation
