Delayed gastric emptying can theoretically affect absorption of oral medications, particularly those with narrow therapeutic windows
Typically, GLP-1 secretion in response to oral glucose is more pronounced than that in response to other administration routes 37 , suggesting a significant opportunity for future investigations to directly examine the analgesic effects of oral glucose through its impact on GLP-1 levels
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Novo Nordisk said it remains confident in the benefit-risk profile of our GLP-1 medicines when used consistent with their indications and product labeling. But neither directly addressed a link between GLP-1 drugs and an altered sense of smell
Similarly, in another study conducted by Nathanson et al., infusion of exenatide in male type 2 diabetic patients with chronic heart failure exhibited positive chronotropism and favorable effects on the cardiac index and hemodynamics
However, their use in the perioperative period surrounding major surgeries, like total joint arthroplasty (TJA), remains an area of growing interest and concern
