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Studies of HFrEF patients raised questions about the safety profile of GLP-1RA therapy in this subpopulation

Methods: MEDLINE, EMBASE, CINAHL, and APA PsycINFO databases were searched

They are and therefore behave as macrophage-type myeloid lineage cells

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Treatment of mice with DS-induced colitis (resembling human ulcerative colitis) with the human GLP-2 analog h(Gly 2 )GLP, twice daily for 10 days, reverses weight loss independent on food intake, decreases interleukin-1 expression and increased colon length, crypt depth, and mucosal area compared to treatment with saline (Drucker et al., 1999)