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This shift makes a calorie deficit more achievable without relying on willpower alone

This microvascular rarefaction is likely a key contributor to the reduced muscle endurance observed in IGF- 1R KD mice, as capillary networks are critical for sustaining aerobic metabolism and preventing muscle fatigue [58, 62, 63]

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doi: 10.1016/j.metabol.2021.154959 33 TurtonNCufflinNDewsburyMFitzpatrickOIslamRWatlerLLet al

Antioxidant supplements and endurance exercise: current evidence and mechanistic insights

Off-label use for weight loss is not advisable without physician guidance