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The persistence of effects without continuous receptor occupation suggests DSIP may trigger gene expression changes rather than requiring constant pharmacological presence
It plays a central role in neutralizing free radicals, supporting liver detoxification, regulating immune function, and protecting cells from oxidative damage
39,40 In addition, there were no strong clinical evidences showing the application of either GLP-1RA or SGLT-2i has the positive effect on the diabetic retinopathy
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Lopes-Virella MF, Stone P, Ellis S, Colwell JA
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