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Archived from the original on 15 February 2026

doi: 10.1001/jamainternmed.2025.1133, PMID: [DOI] [PubMed] [Google Scholar] 55

One has to balance all of this with the understanding that these drugs will cause weight loss in any patient who takes them, he says

doi:10.1056/NEJMoa2302392 200

Temperature sensitivity is not listed as a primary side effect in clinical trials of semaglutide, but patient-reported experiences suggest it occurs in a meaningful subset of usersparticularly those with rapid weight loss or larger initial body mass

Liraglutide has shown significant weight loss compared with placebo with the majority of participants achieving more than 5% total body weight loss during the follow up period and 33% (vs 10%) achieving 10% total body weight loss or greater