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Patients should never discontinue therapy without medical guidance, particularly when prescribed for diabetes management, as abrupt cessation can destabilize glycemic control

You may also receive guidance on your starting dose and how the medication will be gradually adjusted over time

This could prevent you from losing weight

It has recently been shown that GLP-1R neurons in the dorsomedial hypothalamic nucleus regulate pancreatic activity by affecting the dorsal motor nucleus of the vagus, specifically lowering blood glucose levels by increasing insulin release (Huang et al., 2022)

Why Weight Loss Matters for Diabetes Weight loss in diabetic patients produces benefits that extend far beyond the scale: Improved insulin sensitivity: Each 5% of body weight lost meaningfully improves how cells respond to insulin

"Then I try to steer them toward tirzepatide because it's somewhat more effective for weight loss," he says