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In addition, both TTP and gAgAP downregulated transcription levels of angiotensin II receptor type 1 ( agtr1 ) and miR-132/-212, with TTP producing a comparable reduction in agtr1 to captopril and a significant decrease in miR-132/-212 expression

"One-year topical stabilized retinol treatment improves photodamaged skin in a double-blind, vehicle-controlled trial." J Drugs Dermatol

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And this activates inflammatory pathways

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Standard IM repletion often involves 1000 mcg daily for 1 week, then weekly for 4 weeks, followed by monthly maintenance