Its synthesis occurs in two broad sites, the pineal gland and various extra-pineal tissues
Sites should be rotated with each dose to avoid skin irritation
If you develop unexplained muscle symptoms whilst taking both medicines, contact your GP, as this may require investigation Liver function : For statins, NICE recommends liver function tests at baseline, 3 months, and 12 months
Here is a list of potential side effects associated with metformin: Nausea Vomiting Diarrhea Abdominal discomfort or cramping Loss of appetite Lactic acidosis (a rare but serious side effect): weakness, unusual muscle pain, trouble breathing, dizziness, lightheadedness, fast or slow heart rate Vitamin B12 deficiency with long-term use Metallic taste in the mouth Hypoglycemia (low blood sugar), especially when used with other diabetes medications Skin reactions: rash, itching, redness Changes in taste perception Respiratory issues: shortness of breath Liver problems: elevated liver enzymes Individual reactions to metformin can vary, and not everyone will experience these side effects
Traditional strategies to cut obesity have focused on diet and exercise
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