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However, AKERO-001 is expressed in prokaryotic cells, and our experiment suggests that eukaryotic-expressed FGF21-Fc is significantly more stable and consequently more efficacious than the prokaryotic-expressed proteins

The role of endocrine hormones and growth factors are interlinked, often being involved in the same cellular functions leading to crosstalk between the pathways and demonstrating bi-functional roles

Bulk reverse transcription was performed in a high-salt buffer to shield electrostatic interactions between nucleic acids and minimize the stochastic transfer of mRNA across beads 29 (Fig

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Bolke, and Z

Pyrazole-triazole hybrid analogs as selective cyclooxygenases-2 (COX-2) inhibitors with cardioprotective effects As previously discussed, the sulfonyl/sulfonamide motif is a characteristic pharmacophore group for selective COX-2 inhibition