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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have garnered recognition as potentially revolutionary therapeutic modalities for MASLD/MASH management, offering multifaceted benefits extending beyond glycemic regulation

With shortages of the branded drugs declared over, and the window for compounding copies closed, though, some virtual care companies are emerging as unlikely allies

Inhibition of SGLT2 reduces sodium reabsorption in the proximal tubule and enhances Na + delivery to the macula densa, promoting finally the TGF activation with consequent afferent arteriole vasoconstriction and reduction of the single-nephron-glomerular-filtration-rate ( Figure 1 )

PMID: 69 CiaffiJMitselmanDMancarellaLBrusiVLisiLRuscittiPet al

The thyroid GLP-1 connection- how much does increasing detection and ascertainment bias contribute to possible associations with GLP-1 medicines

The researchers say the results support conducting clinical trials specifically designed to test GLP-1 drugs as addiction treatments, including studies capable of measuring effects on overdose and drug-related death