While this idea has been around for a long time, the scientific consensus is murky at best
When your gut bacteria eat it, they produce short-chain fatty acids , which tell your body to make more GLP-1
Regulatory approval has come only for patients with proven genetic defects in the leptin-melanocortin pathway
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Reactive astrocytes have been shown to exert cytotoxicity, and as their activation intensifies, astrogliosis contributes to pathological features such as fibril accumulation, vascular damage, and BBB disruption (Liddelow et al., 2017
So I think whats happened in the last two decades is there has been a substantial update in reconsideration of whats causing major, very severe mental disorders, e.g., major depression, bipolar disorder, schizophrenia