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5.1 Intervention strategies 5.1.1 Targeting iron homeostasis Iron chelators such as deferoxamine, deferiprone, and deferasirox bind free ferrous iron (Fe2+), reducing substrate availability for the Fenton reaction and thereby curtailing the lipid peroxidation cascade (152)

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The main antioxidant enzymes are SOD, GPx and catalase, however in human plasma there is very little or no catalase activity (6, 7)