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IGF-1 LR3s non-selective receptor activation stimulates collagen synthesis and chondrocyte proliferation in cartilage, tendons, and ligaments not just skeletal muscle

This approach ensures that the patient receives the therapeutic benefits while minimizing potential discomfort or complications

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The brain regions involved include the hypothalamus, hippocampus, and brainstem, which express GLP-1 receptors

Competing interests The authors declare that there were not any commercial or financial relationships that could be construed as a potential conflict of interest