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(32(2)):288-293 doi:10.1097/MEG.0000000000001748

Dose escalationthough sometimes necessaryis less reliable than medication switching for breaking true tolerance

In elderly and debilitated patients, it is recommended that the dosage be limited to the smallest effective amount to preclude the development of ataxia or oversedation (2 mg to 2 mg once or twice daily, initially, to be increased gradually as needed and tolerated)

Early detection and a comprehensive approach ensure effective treatment and promote overall well-being

This effect can be mitigated by the application of ferroptosis antagonists