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Research on HGF/c-Met signaling in other biological contexts demonstrates receptor internalization beginning around 4872 hours of sustained activation, with maximal downregulation occurring by day 57 of continuous agonist exposure

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If we can target the treatment there, we may be able to maintain the positive effects while reducing side effects, says Jlia Teixidor-Deulofeu, first author of the study and PhD student at Sahlgrenska Academy at the University of Gothenburg

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Beyond the immediate onset, others describe a delayed or intermittent pattern

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