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12 The substitution of GLP-1 Thr 13 or GIP Ile 7 with Ala obviously decreased their receptor-activating activities 25,26 and the substitution of GIP Ile 7 with Thr decreased its cAMP activity (pEC 50 : 9.769.58;Emax: 9.918.90)

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The appetite reduction causes patients to consume less food without experiencing hunger

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Correlating the global signal with the time series of each voxel (Pearsons correlation) yields a whole-brain correlation, which is also considered a weighted form of functional connectivity density [42]

doi: 10.2337/diab.42.5.658 95 ReedJBainSKanamarlapudiV