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It can also lead to electrolyte imbalances

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In addition to the neuropharmacological effects of GIPR antagonism, we also demonstrate that CNS GIPR KO prevents body weight gain under HFD challenge, supporting the role of CNS GIPR as a primary driver of body weight differences seen in the whole-body GIPR KO mouse 41

These effects are often dose-related and may lessen as the body adjusts to the medication

Having a gap in treatment often leads to weight regain