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As of 2026, neither peptide is named in the schedules of the Misuse of Drugs Act 1971 or its associated Misuse of Drugs Regulations [unverified], so they are not controlled drugs

Conversely, expression of GPD2 and LEPROTL1, genes linked to metabolic stress and reduced leptin sensitivity, was increased (Segerstolpe et al., 2016)

Regression of cardiac hypertrophy in health and disease: mechanisms and therapeutic potential

Drugs (some antimalarials, chemotherapeutic agents, sulfonamides, sulphones, antipyretics, analgesics, the diabetic agent glibenclamide, the gout treatment agent urate oxidase and miscellaneous)

R., Kurland, I

Nature , 432 (7016), 466472.