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Due to this interdependent relationship, gut dysbiosis, a compositional and functional alteration of GM (Levy et al., 2017), may influence host susceptibility to many immune-mediated diseases such as RA, type 1 diabetes, multiple sclerosis, and systemic lupus erythematosus (Zhong et al., 2018)

It signals fibroblasts to produce collagen and elastin, accelerates wound and tissue remodeling, and shifts gene expression toward repair