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All living organisms, be yeasts or protozoa, plants or animals express the glucose-6-phosphate dehydrogenase enzyme (G6PD) 1

8 , e2994 (2018)

9 , 80 Central GLP1R activation also suppresses TLRdriven cytokine induction (e.g., TNF) via neuronal GLP1Rs, indicating a direct central mechanism beyond peripheral metabolic effects

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Specifically, beyond the enteroendocrine L-cells of the intestine, GLP-1 is also produced as a neuropeptide by the pre-proglucagon neurons in the brain stem 3

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