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After the bezafibrate infarction prevention (BIP) study, a subgroup analysis found that bezafibrate lowers myocardial infarction (MI) in CHD patients

Pharmacokinetic Analysis: No Shared Metabolic Pathways The core reassurance with this combination is that GHK-Cu and metformin use entirely separate pharmacokinetic pathways, making a direct drug-drug interaction unlikely at the absorption, distribution, metabolism, or excretion level

This efficacy limitation, rather than safety concerns, halted further development

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