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Free from the acyl group, carnitine can be transported back out of the matrix by CACT and re-used for LCFA shuttling

p53 transcriptionally activates the expression of GLS2 (Jennis et al., 2016) and SAT1 (Ou et al., 2016) (a polyamine catabolic enzyme) and transcriptionally represses SLC7A11 (Jiang et al., 2015)

This is exceedingly rare with high-purity peptides like those from our collection, but it's a critical safety check