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however, clinical treatment still faces numerous challenges: 30%-40% of patients exhibit primary or secondary non-response to existing therapeutic regimens such as biologics and small-molecule drugs, and prolonged administration tends to induce significant side effects

Curr Treat Options Neurol 19:111 Nelson JC (1997) Safety and tolerability of the new antidepressants

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Hales CM, Carroll MD, Fryar CD, Ogden CL

For a complete overview of factors that affect how long semaglutide stays good , light protection is often overlooked but matters for long-term stability

They may also increase the risk of adverse events or severe side effects due to improper dosing