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However, the faster it builds up, the worse you feel

Normally, very large amounts of quercetin are nutritionally required to achieve some its health benefits because it's not very "bioavailable" or easy for the body to take up and use, since it's not water-soluble

Hammadeh, M., Hamad, M., Montenarh, M

Santangelo, F., Witko-Sarsat, V., Dreke, T

It plays a crucial role in various physiological processes and is primarily taken as a supplement because it is a powerful antioxidant that helps protect cells from oxidative stress and damage caused by free radicals

It has to do with focal actin kinases which act with GiActin in the extracellular matrix