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doi: 10.3390/jcm11092491
Fat stored around internal organs in the abdominal cavity, associated with increased metabolic and cardiovascular disease risk compared to subcutaneous fat stored under the skin
Some clinicians use it as an adjunct rather than a replacement for systemic subcutaneous dosing
When combined, the two therapies appear to work synergistically for greater weight loss
Hypoglycemia symptoms such as shakiness, sweating, confusion, or rapid heartbeat are particularly important in patients taking tirzepatide in combination with insulin or sulfonylureas
Several biological pathways have been proposed, though the evidence in humans remains limited for many of these hypotheses
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