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Providers can bypass step therapy by documenting contraindications to first-line agents such as skin irritation from topicals or patient non-compliance with daily application

Comment: Many commenters supported the proposal to decrease the amount of time an ACO can participate under a one-sided model under the BASIC track's glide path from 7 to 5 years

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Response: We appreciate this commenter's request for additional information and justification as to why heart failure and low back pain were selected for the model

By combining these agents in a single injection, the formulation may improve patient adherence to treatment protocols while potentially reducing the burden side effects or and multiple injections or medications, as determined by necessary by the prescribing physician

The gradual reduction allows assessment of the minimum effective dose for each individual