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Direct innervation of the PB by neurons originating in the NTS and AP in the brainstem and in the hypothalamic ARH have been demonstrated (88, 89), suggesting an activation pathway for endogenous blood-borne hormones, such as leptin (27), ghrelin (90), and GLP-1 (8), that affects PB signaling

It transports fatty acids into the mitochondria the cellular powerhouses

These observations were interpreted as potentially consistent with altered photoreactivity, though inter individual variability and study design limitations were noted as relevant considerations

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