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Optimization of potent ligands for the E3 ligase DCAF15 and evaluation of their use in heterobifunctional degraders

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demonstrated that liraglutide reduced pathology-specific tau phosphorylation and improved motor function in a transgenic hTauP301L mouse model of tauopathy [57]

With the data we have so far, this appears to be anywhere from a 10-15 pound, on average, weight gain after stopping the drugs

However, in specific contexts, GLP-1 has also been shown to exhibit cytotoxic effects