Important Considerations for Combining NAD+ and AOD9604 Despite the theoretical appeal, several crucial points must be considered when exploring the combination of NAD+ and AOD9604: Lack of Direct Combined Research: The most significant caveat is the current lack of extensive human clinical trials specifically investigating the combined effects of NAD+ precursors and AOD9604
In this context, PEPITEM and its derivatives show steroid-like activity, including suppression of leukocyte trafficking and inflammatory cytokines, supporting its use alongside existing therapies
Also, CoQ10 (1.5 mg/kg, dissolved in serum physiologic administrated daily for 15 days by gavage) showed a decreasing effect on increasing induced- and endothelial nitric oxide synthase (iNOS and eNOS) expression levels in the hyperthyroid heart (Oztay et al., 2007)
As kidney disease progresses, imbalanced sodium levels become more likely
While promising, evidence is limited to preclinical data with no registered clinical trials to date, and thus human efficacy and safety remain to be established
Cell Metab 13(4):461468 Batiha GE, Al-Gareeb AI, Rotimi D, Adeyemi OS, Al-Kuraishy HM (2022) Common NLRP3 inflammasome inhibitors and Covid-19: divide and conquer
