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Hydroxysafflor yellow A inhibits endothelial cell ferroptosis in diabetic atherosclerosis mice by regulating miR-429/SLC7A11

retatrutide data are at 48 weeks only Population differences : Participant demographics, baseline BMI, and comorbidity profiles may differ Dose optimization : Retatrutide's Phase 3 may use different doses than Phase 2 A head-to-head randomized trial would be needed to definitively establish relative efficacy

JAMA Cardiol 6(2):148158

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The mechanism is obesity-specific in mice

26 Further evidence is provided by the finding that the reduction of lipid accumulation in the liver is more prominent than that in the heart and skeletal muscle