It is not just the load -- it is the combination of load, volume, and variety
Elevated homocysteine and methylmalonic acid (MMA) are biomarkers of functional B12 insufficiency
Seek medical advice if you are taking B12 supplements and experience: Persistent skin changes, particularly acne-like eruptions or rosacea worsening Unexplained headaches or dizziness that coincide with supplement use Gastrointestinal symptoms including nausea or abdominal discomfort Any allergic reactions such as rash or itching Call 999 or go to A&E immediately if you experience: Difficulty breathing Swelling of the face, lips, tongue or throat Severe rash or itching Other symptoms of severe allergic reaction after taking B12 These symptoms warrant review of your supplementation regimen
In human SH-SY5Y neuroblastoma cells, a well-established model for studying neuronal behavior, Epitalon significantly increased the secretion of soluble amyloid precursor protein (sAPP) by ~20%
This decreases inflammatory cell infiltration and protects surrounding tissues from secondary damage 4
Carbon Research (2023) 2(1)