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In fact, we observed that bTNF- increases extracellular L-lactate in bFLS

Indirect calorimetry showed that KO mice displayed a higher respiratory exchange ratio (RER), indicative of a shift toward carbohydrate utilization

This oxidative stress, likely driven by altered neurotransmitter signaling and cellular metabolism, is thought to contribute to schizophrenia-related deficits in inhibitory interneuron populations, including parvalbumin-positive cells (Li et al., 2024)

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Orforglipron (LY3502970), a novel, oral non-peptide glucagon-like peptide-1 receptor agonist: a Phase 1a, blinded, placebo-controlled, randomized, single- and multiple-ascending-dose study in healthy participants