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N Engl J Med 2025;393:26-36 [7] Kruger et al

Association of patient-centered outcomes with patient-reported and ICD-9-based morbidity measures

Further, KD should not be used in patients with chronic kidney disease, liver failure, hypertriglyceridemia-induced acute pancreatitis, heart failure, especially NYHA Class IV, eating disorders, respiratory failure, as well as in the elderly, and during pregnancy and lactation ( KD is widely used as an adjuvant therapy for many diseases

Tirzepatide (Mounjaro) Tirzepatide is unique because it targets two hormones: GLP-1 and glucose-dependent insulinotropic polypeptide (GIP)