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Comparison Table: Retatrutide vs Tirzepatide Side Effects and Safety Profile Common Side Effects (Both Medications) Both tirzepatide and retatrutide share a similar gastrointestinal side effect profile, which is characteristic of incretin-based therapies: Nausea (most common, typically transient) Diarrhea Constipation Vomiting Decreased appetite Abdominal discomfort Fatigue These effects are generally mild to moderate and tend to diminish as the body adjusts to the medication, particularly when doses are titrated gradually

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