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Increased intestinal permeability is facilitated by a high-fat diet (HFD) 22 , and may allow for bacterial translocation from the gut to adipose tissue 23

Studies found that these bacteria promoted regular bowel movements (10)

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Interestingly, the strong dependence of mitochondrial -oxidation on autophagic and fatty acid (FA) catabolic processes makes some tumors more resistant to nutrient deprivation and environmental stressors 13

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Because chronic inflammation is strongly associated with metabolic dysfunction, this mechanism has generated interest among researchers studying metabolic disease