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The FDA Wegovy label lists nausea, diarrhea, vomiting, and constipation among the most common reactions (incidence 5 percent or higher), and the most common reasons for stopping were nausea (1.8 percent), vomiting (1.2 percent), and diarrhea (0.7 percent)

Siegel said he prefers to start teens on three to six months of intensive lifestyle management before even considering medication

Each capsule is encased in a plant-based, delayed-release, and acid-resistant capsule, ensuring safe passage through the stomach and into the gut microbiome.

Oct 2015;21(10):1269-72

Rotating sites prevents tissue irritation and injection site reactions

Semaglutide treatment commenced at 0.25 mg per week for the initial 4 weeks using a pre-filled pen injector, with a fixed-dose escalation every 4 weeks until reaching the maintenance dose of 2.4 mg by week 16 (lower maintenance doses allowed if 2.4 mg was intolerable for participants)