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Certain medications deplete folate levels

If youve searched for tirzepatide side effects or semaglutide side effects, youve probably noticed similar lists: nausea, vomiting, constipation, diarrhea, and occasional fatigue

The complementary mechanisms also mean that side effects are generally not additive, though gastrointestinal symptoms may occur with both medications and require careful management during the initiation phase

PubMed Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease Useful when liver-fat claims involve next-generation incretin or pipeline agents

Additionally, alcohol can exacerbate gastrointestinal side effects such as nausea and may contribute to dehydration if combined with vomiting or diarrhea caused by the medication

For all new drugs, a thorough safety profile needs to be established, with particular emphasis on cardiovascular safety