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The pKa, of imidazole rings varies according to the microenvironment that protein folds in, and this huge pKa fluctuation enables the proteins histidine binding with metals ( 2+ )

Masaldan S, Clatworthy SAS, Gamell C, Meggyesy PM, Rigopoulos AT, Haupt S

Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial

Cumulus cells accelerate oocyte aging by releasing soluble Fas Ligand in mice

However, glutathione is sensitive to environmental factors, which can compromise its potency: Temperature: Elevated temperatures can accelerate the degradation of glutathione bulk powder

These results indicate that NP4 are able to fully penetrate the three-dimensional cellular structure and generate a cytotoxic effect in multicellular tumor spheroids