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MB is well known to promote complex IV activity and mitochondrial activity and this effect extends to the AD brain [107,26]

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Secondly, the combination of different functional nanoagents may cause corresponding toxic side effects to the human body, thus the biodegradability, stability, and safety of nanomedicines still need further validation

Conventional randomized controlled trials, long regarded as the gold standard, often fail to accommodate the biological heterogeneity, comorbidities, and evolving pathophysiological trajectories that characterize chronic brain diseases