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The cell-surface transmembrane E3 ubiquitin ligases Zinc and Ring Finger 3 (ZNRF3) and Ring Finger Protein 43 (RNF43) act as negative feedback regulators of Wnt/-catenin signaling by inducing the degradation of FZD and LRP6 in a DVL-dependent manner, and R-spondin (RSPO) ligand binding to leucine-rich repeat-containing G protein-coupled receptor (LGR) 4/5 receptors can clear ZNRF3 and RNF43 to strengthen Wnt/-catenin signaling

Hit & Run model of closed-skull traumatic brain injury (TBI) reveals complex patterns of post-traumatic AQP4 dysregulation

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At least 10,000 cells per sample were evaluated

Mesenchymal stem cell transplantation for vaginal repair in an ovariectomized rhesus macaque model [J]

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