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While the exact mechanisms underlying these gastrointestinal disturbances remain incompletely elucidated, they are believed to stem from the actions of GLP-1 RAs on gastrointestinal motility and secretion [6]
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What are GLP1 Drugs
Mechanistically, hyperactivation of Drp1 suppresses hexokinase 1 (HK1), a glycolytic enzyme localized to the mitochondria, inducing metabolic reprogramming that promotes NLRP3-driven inflammation and oligodendrocyte pyroptosis (Pradeepkiran and Reddy, 2020
However, this model did not outperform a simple reinforcement learning model which estimates a single RPE sensitivity using all trials suggesting that increased model complexity was not justified by the data from this paradigm
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