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Because the compound acts on receptors central to energy metabolism, researchers note that its effects on metabolic and cardiovascular parameters are still being investigated

- [Retatrutide Phase 2 Trial Supplementary Appendix: Drug Preparation]( *New England Journal of Medicine*, 2023

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Poultry, meat, fish, and dairy products are food sources of vitamin B-12

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Tirzepatide causes thyroid C-cell tumors in rats, and although its unknown whether tirzepatide causes thyroid C-cell tumors in humans, it is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)