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More than three cardiovascular risk factors without established CVD or CKD: Weak recommendation for starting SGLT-2 inhibitors and weak against starting GLP-1 receptor agonists

Clinical studies specifically monitoring glucose metabolism through oral glucose tolerance tests found no significant changes in glucose handling, and fasting insulin levels remained stable throughout treatment periods lasting up to 24 weeks

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2016 Sep;29(3):421-5 (Ver) Showell MG, Mackenzie-Proctor R, Brown J, Yazdani A, Stankiewicz MT, Hart RJ